Manuscript describing rAMPage, a novel AMP discovery pipeline, published today
news ·Our manuscript presenting rAMPage: Rapid Antimicrobial Peptide Annotation and Gene Estimation has been published in Antibiotics. Antimicrobial peptides (AMPs) hold great potential as effective alternatives to small molecule antibiotics in the race against antibiotic resistance. In this manuscript, we present rAMPage, a scalable high-throughput bioinformatics pipeline for AMP discovery, and demonstrate its utility in the discovery of 7 active AMPs from amphibian and insect transcriptomes. These 7 active AMPs have been shown to be active against E. coli and S. aureus with minimal toxicity, and are promising candidates for further development in therapeutics. rAMPage is freely available on GitHub.